Living Tissue Manufacturing with Symbiotic Materials

Overview

PRISM-LT aims to shape the future of engineered living materials in the European Union by developing an adaptable bioprinting platform—targeting biomedical and food applications—and addressing the main issues in adopting these technologies. 

Funding

The project is co-funded by the European Union and the European Innovation Council under the Pathfinder Engineered Living Materials Challenge 

European innovation council: Co-funded by the European Union

Approach

The PRISM-LT platform plans to innovate several aspects of biomanufacturing.

Tuneable bioink

A support matrix with tuneable properties integrates stem cells and engineered helper microorganisms.

Engineered microorganisms

Engineered bacteria or yeast probe the environment and support stem cell differentiation.

Self-regulated communications

Living tissues with optimised production and long-term viability thanks to self-regulating communications between stem cells and microorganisms.

Complex hybrid tissues

Computer-aided bioprinting of structures that interface muscle, fat, and bone: mimicking natural tissues. 

Applications

The project will test its approach and platform by developing hybrid living tissues for two main applications.

Biomedicine

A bone-fat interface to be used as an in-vitro model for preclinical research.

Food production

A muscle-fat interface will serve as a model for manufacturing clean meat with improved natural features.

Consortium

The project includes five partners from four countries.

Three universities, a non-profit company, and a start-up company based in Italy, Sweden, the Netherlands, and the United Kingdom comprise the project’s consortium. In society is the project main coordinator while the University of Glasgow provides scientific coordination.

  • In society: Shaping innovation
  • University of Glasgow
  • Chalmers University of technology
  • Cellink, a Bico company
  • Radboud University
  • University of Aveiro